Academic and research publications

Publications

Chander RJ, Grainger SA, Crawford JD, Mather KA, Numbers K, Cleary R, Kochan NA, Brodaty H, Henry JD, Sachdev PS. Development of a short‐form version of the Reading the Mind in the Eyes Test for assessing theory of mind in older adults. Int J Geriatr Psychiatr 2020;35:1322–1330. doi: 10.1002/gps.5369. Impact factor: 2.675

Yatawara C, Guevarra A, Ng KP, Chander RJ, Kandiah N. Interactions Between Acute Infarcts and Cerebrovascular Pathology Predict Poststroke Dementia. Alzheimer Dis Assoc Disord 2020;34:206–11. doi: 10.1097/WAD.0000000000000384. Impact factor: 2.098

Lo JW, Crawford JD, Samaras K, Desmond DW, Köhler S, Staals J, Verhey FRJ, Bae H-J, Lee K-J, Kim BJ, Bordet R, Cordonnier C, Dondaine T, Mendyk A-M, Le B-C, Yu K-H, Lim J-S, Kandiah N, Chander RJ, Yatawara CJ, Lipnicki DM, Sachdev PS, for the STROKOG Collaboration. Association of Prediabetes and Type 2 Diabetes With Cognitive Function After Stroke: A STROKOG Collaboration Study. Stroke 2020;51:1640–6. doi: 10.1161/STROKEAHA.119.028428. Impact factor: 6.046

Yatawara CJ, Guevarra AC, Ng KP, Chander RJ, Lam BYK, Wong APL, Mok VCT, Kandiah N. The role of cerebral microbleeds in the incidence of post-stroke dementia. J Neurol Sci 2020;412:116736. doi: 10.1016/j.jns.2020.116736. Impact factor: 2.651

Guevarra AC, Ng SC, Saffari SE, Wong BYX, Chander RJ, Ng KP, Kandiah N. Age Moderates Associations of Hypertension, White Matter Hyperintensities, and Cognition. J Alzheimer Dis 2020;75(4):1351–60. Impact factor: 3.909

Chan LG, Sim KSS, Yong TT, Chander RJ, Tan LCS, Kandiah N. The longitudinal impact of excessive daytime somnolence on motor and nonmotor symptoms of Parkinson’s disease in a Southeast Asian cohort. J Geriatr Psychiatr Neurol 2019. First published online: 13 December 2019 (ePub ahead of print). doi: 10.1177/0891988719892326. Impact factor: 2.747

Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae H-J, Lim J-S, Köhler S, Douven E, Staals J, Chen C, Xu X, Chong EJm Akinyemi RO; Kalaria RNm Ogunniyi Am Barbay Mm Roussel Mm Lee B-Cm Srikanth VKm Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema JW, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombois S, Hénon H, Lipnicki DM, Kochan NA, Sachdev PS, Stroke and Cognition (STROKOG) Collaboration. Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups. Neurology 2019;93(24):e2257-e2271. doi: 10.1212/WNL.0000000000008612. Impact factor: 8.689

Grainger SA, Crawford JD, Kochan NA, Mather KA, Chander RJ, Draper B, Brodaty H, Sachdev PS, Henry JD. An investigation into early life stress and cognitive function in older age. Int Psychogeriatr 2019. First published online: 29 October 2019 (ePub ahead of print). doi: 10.1017/S1041610219001583. Impact factor: 2.480.

Low A, Ng KP, Chander RJ, Wong B, Kandiah N. Association of asymmetrical white matter hyperintensities and apolipoprotein E4 on cognitive impairment. J Alzheimer Dis 2019;70:953-964. doi: 10.3233/JAD-190159. Impact factor: 3.517

Yatawara CJ, Ng KP, Lim L, Chander RJ, Zhou J, Kandiah N. Cerebrovascular disease is a risk for getting lost behavior in prodromal dementia. Am J Alzheimer Dis Other Dement 2019;34(5):344-352. doi: 10.1177/1533317519852864. Impact factor: 1.602

Yatawara CJ, Lee DR, Ng KP, Chander RJ, Ng DE, Ji F, Shim HY, Hilal S, Venketasubramanian N, Chen CLH, Zhou J, Kandiah N. Mechanisms linking white matter lesions, tract integrity, and depression in Alzheimer disease. Am J Geriatr Psychiatr 2019;27(9):948-959. doi: 10.1016/j.jagp.2019.04.004. Impact factor: 3.480

Low A, Yatawara CJ, Yong TT, Chander RJ, Ng KP, Kandiah N. Predictors and patterns of cognitive decline differ between mild cognitive impairment in Parkinson’s disease (PD-MCI) and Alzheimer’s disease (AD-MCI). J Alzheimer Parkinsonism Dement 2019;3(1):027.

Chander RJ, Foo H, Yong TT, Lim L, Tan YJ, Wen MC, Ng ASL, Hameed S, Ting SKS, Zhou J, Kandiah N. Serial position effects differ between Alzheimer’s and vascular features in mild cognitive impairment. Aging 2018;10(12):3866-3880. doi: 10.18632/aging.101678. Impact factor: 5.179

Vipin A, Foo H, Lim JKW, Chander RJ, Yong TT, Ng ASL, Hameed S, Ting SKS, Zhou J, Kandiah N. Regional white matter hyperintensity influences grey matter atrophy in mild cognitive impairment. J Alzheimer Dis 2018;66(2):533-549. doi: 10.3233/JAD-180280. Impact factor: 3.920.

Yatawara CJ, Ng KP, Chander RJ, Kandiah N. Associations between lesions and domain-specific cognitive decline in poststroke dementia. Neurology 2018;91(1):e45-e54. doi:10.1212/WNL.0000000000005734. Impact factor: 8.320.

Foo H, Ng KP, Tan YJ, Lim L, Chander RJ, Yong TT, Kandiah N. Interaction between APOE-ɛ4 and HMGB1 is associated with widespread cortical thinning in mild cognitive impairment. J Neurol Neurosurg Psychiatr 2018;89(2):225-226. Impact factor: 7.349.

Chander RJ, Lam BYK, Lin X, Ng AYT, Wong APL, Mok VCT, Kandiah N. Development of a risk score (CHANGE) for cognitive impairment after ischemic stroke. Sci Rep 2017;7(1):12441. Impact factor: 4.259.

Chander RJ, Lim L, Handa S, Hiu S, Choong A, Lin X, Singh R, Oh DCT, Kandiah N. Atrial fibrillation is independently associated with cognitive impairment after ischemic stroke. J Alzheimer Dis 2017;60(3):867-875. Impact factor: 3.920.

Ong MT, Foo H, Chander RJ, Wen MC, Au WL, Sitoh YY, Tan LCS, Kandiah N. Influence of diabetes mellitus on longitudinal atrophy and cognition in Parkinson’s disease. J Neurol Sci 2017;377:122-126. Impact factor: 2.126

Tan J, Ng A, Vipin A, Lim JKW, Chander RJ, Ji F, Qiu Y, Ting SKS, Hameed S, Lee TS, Zeng L, Kandiah N, Zhou J. Higher peripheral TREM2 mRNA levels relate to cognitive deficits and hippocampal atrophy in Alzheimer’s disease and amnestic mild cognitive impairment. J Alzheimer Dis 2017;58:413-423. Impact factor: 3.920

Lin X, Yu WY, Liauw L, Chander RJ, Soon WE, Lee HY, Tan K. Clinicoradiologic features distinguish tumefactive multiple sclerosis from CNS neoplasms. Neurol Clin Pract 2017;7:1-12. Impact factor: 0.490

Foo H, Mak E, Chander RJ, Ng A, Au WL, Sitoh YY, Tan LCS Kandiah N. Associations of hippocampal subfields in the progression of cognitive decline related to Parkinson’s disease. Neuroimage Clin 2017;14:37-42. Impact factor: 3.857

Sachdev PS, Lo JW, Crawford JD, Mellon L, Hicker A, Williams D, Bordet R, Mendyk AM, Gele P, Deplanque D, Bae HJ, Lim JS, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong YH, Tan HH, Chen C, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee BC, Yu KY, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin XL, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Lipnicki DM, Kochan NA. STROKOG (Stroke and Cognition Consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease. Alzheimers Dement: Diagn Assess Dis Monit 2017;7:11-23.

Wee N, Wen MC, Kandiah N, Chander RJ, Ng A, Au WL, Tan LCS. Neural correlates of anxiety in mild Parkinson’s disease: A prospective longitudinal voxel-based morphometry study. J Neurol Sci 2016;371:131-136. Impact factor: 2.126

Foo H, Mak E, Yong TT, Wen MC, Chander RJ, Au WL, Sitoh YY, Tan LCS, Kandiah N. Progression of subcortical atrophy in mild Parkinson’s disease and its impact on cognition. Eur J Neurol 2016;24(2):341-348. Impact factor: 3.956

Yatawara CJ, Lim L, Chander RJ, Zhou J, Kandiah N. Depressive symptoms influence global cognitive impairment indirectly by reducing memory and executive function in patients with mild cognitive impairment. J Neurol Neurosurg Psychiatr 2016;87:1375-1383. Impact factor: 6.807

Foo H, Mak E, Yong TT, Wen MC, Chander RJ, Au WL, Tan LCS, Kandiah N. Progression of small vessel disease correlates with cortical thinning in Parkinson’s disease. Parkinsonism Relat Disord 2016;31:34-40. Impact factor: 3.794

Wee N, Kandiah N, Acharyya S, Chander RJ, Ng A, Au WL, Tan LCS. Depression and anxiety are co-morbid but dissociable in mild Parkinson’s disease: A prospective longitudinal study of patterns and predictors. Parkinsonism Relat Disord 2016;23:50-56. Impact factor: 4.126

Wee N, Kandiah N, Acharyya S, Chander RJ, Ng A, Au WL, Tan LCS. Baseline predictors of worsening apathy in Parkinson’s disease: A prospective longitudinal study. Parkinsonism Relat Disord 2016;23:95-98. Impact factor: 4.126

Kandiah N, Chander RJ, Lin XL, Ng A, Poh YY, Cheong CY, Cenina AR, Assam PN. Cognitive impairment after mild stroke: Development and validation of the SIGNAL2 Risk Score. J Alzheimers Dis 2015;49(4):1169-1177. Impact factor: 4.151.

Ng A, Chander RJ, Tan LCS, Kandiah N. Influence of depression in mild Parkinson’s disease on longitudinal motor and cognitive function. Parkinsonism Relat Disord 2015;21:1050-1060. Impact factor: 4.126

Wen MC, Ng A, Chander RJ, Au WL, Tan LCS, Kandiah N. Longitudinal brain volumetric changes and their predictive effects on cognition among cognitively asymptomatic patients with Parkinson’s disease. Parkinsonism Relat Disord 2015;21:483-488. Impact factor: 4.126

Kandiah N, Chander RJ, Ng A, Wen MC, Cenina AR, Assam PN. Association between white matter hyperintensity and medial temporal atrophy at various stages of Alzheimer’s disease. Eur J Neurol 2015;22:150-155. Impact factor: 4.162

Kandiah N, Zainal NH, Narasimhalu K, Chander RJ, Ng A, Mak E, Au WL, Sitoh YY, Nadkarni NV, Tan LCS. Hippocampal volume and white matter disease in the prediction of dementia in Parkinson’s disease. Parkinsonism Relat Disord 2014;20:1203-1208. Impact factor: 4.126

Kandiah N, Chander RJ, Zhang A, CY Cheong. Cerebral white matter disease is independently associated with BPSD in Alzheimer’s disease. J Neurol Sci 2014;337(1-2):162-166. Impact factor: 2.413

Conference presentations

Chander RJ, Numbers K, Grainger SA, Cleary R, Das D, Mather KA, Kochan NA, Brodaty H, Henry JD, Sachdev PS. Social cognitive abilities in older adults with mild cognitive impairment and dementia. Presented at: The 2020 Alzheimer’s Association International Conference; 2020 July 29 [virtual event].

Chander RJ, Mather K, Cleary R, Grainger SA, Kochan NA, Henry JD, Sachdev PS. Influence of oxytocin receptor (OXTR) rs53576 on cognitive and affective empathy in healthy adults: A meta-analysis [Lightning talk]. Presented at: 14th GeneMappers Conference; 2019 November 20-22; Manly NSW, Australia.

Chander RJ, Foo H, Yong TT, Lim L, Tan YJ, Wen MC, Zhou J, Kandiah N. Serial position effect profiles of recall in mild cognitive impairment: Interplay between hippocampal volumes and white matter hyperintensities. Presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 17; London, UK.

Chander RJ. Validation of a clinically applicable risk score for cognitive impairment after ischemic stroke. Presented at: The SingHealth Duke-NUS Scientific Congress 2016; 2016 September 23; Singapore.

Chander RJ. Prevalence of silent cerebral ischemia in Alzheimer’s disease and its association with medial temporal atrophy. Presented at: National Neuroscience Institute Research Day 2013; 2013 July 19; Singapore.

Abstracts

Chander RJ, Mather K, Cleary R, Grainger SA, Kochan NA, Henry JD, Sachdev PS. Influence of oxytocin receptor (OXTR) rs53576 on cognitive and affective empathy in healthy adults: A meta-analysis. Abstract presented at: 14th GeneMappers Conference; 2019 November 20-22; Manly NSW, Australia.

Cleary R, Numbers K, Chander RJ, Crawford JD, Kochan NA, Sachdev PS, Brodaty H, Draper B. The relationship between severity of childhood trauma and cognitive decline in older adults. Abstract presented at: The 20th Australian Conference on Traumatic Stress; 2019 September 12-14; Sydney NSW, Australia.

Lo JW, Crawford JD, Desmond DW, Godefroy O, Jokinen H, Mahinrad S, Bae HJ, Lim JS, Koehler S, Douven E, Staals J, Chen C, Xu X, Chong E, Akinyemi RO, Kalaria RN, Ogunniyi A, Barbay M, Roussel M, Lee BC, Srikanth VK, Moran C, Kandiah N, Chander RJ, Sabayan B, Jukema W, Melkas S, Erkinjuntti T, Brodaty H, Bordet R, Bombios S, Hénon, Lipnicki DM, Kochan NA, Sachdev PS. Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups. Abstract presented at: The 2019 Alzheimer’s Association International Conference; 2019 July 14-18; Los Angeles, CA, USA.

Low A, Ng KP, Chander RJ, Wong B, Kandiah N. Association of symmetrical white matter hyperintensities and apolipoprotein e4 on cognitive impairment. Abstract presented at: The 2019 Alzheimer’s Association International Conference; 2019 July 14-18; Los Angeles, CA, USA.

Chander RJ, Das D, Mather KA, Kochan NA, Riches J, Grainger SA, Wright M, Brodaty H, Henry JD, Sachdev PS. Social cognitive performance in octogenarians and nonagenarians. Abstract presented at: The 2nd International ‘Living To 100’ Conference; 2018 September 7-8; Sydney NSW, Australia.

Yatawara CJ, Kandiah N, Chander RJ. Acute infarcts interact with pre-stroke cerebral and vascular pathology to predict early-onset dementia. Abstract presented at: The 2018 Alzheimer’s Association International Conference; 2018 July 22-26; Chicago, IL, USA.

Low A, Yatawara CJ, Yong TT, Chander RJ, Ng KP, Kandiah N. Mild cognitive impairment associated with Parkinson’s disease (PD-MCI) and MCI associated with Alzheimer’s disease (AD-MCI) have distinct cognitive profiles: A longitudinal study. Abstract presented at: The 2018 Alzheimer’s Association International Conference; 2018 July 22-26; Chicago, IL, USA.

Lim AWL, See CJC, Lim L, Chander RJ, Yong TT, Ting SKS, Hameed S, Kandiah N, Ng ASL. Differentiating frontal variant Alzheimer’s disease from behavioral variant frontotemporal dementia. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-20; London, UK.

Lim LLH, Chua EV, Chander RJ, Ng ASL, Kandiah N, Silva E. Relevance of community cognitive screening: Experience from Singapore. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-20; London, UK.

Yong TT, Chander RJ, Foo H, Lim L, Ng AYT, Tan LCS, Kandiah N. Voxel-based morphometric comparison study of mild cognitive impairment in Alzheimer’s disease and Parkinson’s disease. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-20; London, UK.

Lim L, Yong TT, Chander RJ, Ting SKS, Hameed S, Ng ASL, Kandiah N. Young onset dementia in a Southeast Asian population from Singapore: Clinical and biomarker characterization. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-20; London, UK.

Chander RJ, Lim L, Handa S, Hiu S, Choog A, Lin XL, Singh R, Oh DCT, Kandiah N. Atrial fibrillation in ischemic stroke survivors is independently associated with episodic memory and executive function impairments. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-21; London, UK.

Chander RJ, Foo H, Yong TT, Lim L, Tan YJ, Wen MC, Zhou J, Kandiah N. Poor serial position effect performance is correlated with reduced cortical and hippocampal volumes un mild cognitive impairment. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-21; London, UK.

Chander RJ, Lam BYK, Lim L, Lin XL, Singh R, Oh DCT, Mok VCT, Kandiah N. Risk factor profiles predicting delayed vascular cognitive impairment in your and old ischemic stroke survivors. Abstract presented at: The 2017 Alzheimer’s Association International Conference; 2017 July 16-20; London, UK.

Chander RJ, Foo H, Yong TT, Lim L, Tan YJ, Wen MC, Zhou J, Kandiah N. Serial position performance as a clinical marker for underlying neurodegeneration and ischemia in genetically vulnerable subjects. Abstract presented at: The 5th Singapore International Neurocognitive Symposium; 2017 March 16-18; Singapore.

Lee DR, Wen MC, Chander RJ, Zhou J, Kandiah N. Structural connectivity analysis reveals white matter aberrations in high risk cardiovascular burden subjects with mild Alzheimer’s disease. Abstract presented at: The 2016 Alzheimer’s Association International Conference; 2016 July 24-28; Toronto, ON, Canada.

Lim LH, Chander RJ, Yong TT, Kandiah N. Subjective cognitive complaints and objective memory deficits in a young-old community cohort. Abstract presented at: The 2015 Alzheimer’s Association International Conference; 2015 July 18-23; Washington, D.C., USA.

Chander RJ, Choong MK, Lim L, Handa S, Kandiah N. The role of chronic cerebrovascular diseases in the development of post stroke cognitive impairment. Abstract presented at: The 2015 Alzheimer’s Association International Conference; 2015 July 18-23; Washington, D.C., USA.

Chander RJ, Choong MK, Lim L, Handa S, Kandiah N. Factors implicated in the varying risk of cognitive impairment across stroke subtypes. Abstract presented at: The 4th Singapore International Neurocognitive Symposium; 2015 May 27-28; Singapore.

Ng A, Chander RJ, Tan LCS, Kandiah N. Influence of depression in early Parkinson’s disease on longitudinal motor and cognitive decline. Abstract presented at: SingHealth Duke-NUS Neuroscience ACP Research Day 2015; 2015 February 6; Singapore.

Zainal NH, Chander RJ, Hameed S, Zhou J, Kandiah N. Influence of small vessel cerebrovascular disease on the neuropsychological performance of patients with early Alzheimer’s disease. Abstract presented at: The SingHealth Duke-NUS Scientific Congress 2014; 2014 September 5-6; Singapore.

Lim LH, Chander RJ, Nyu MM, Choong TM, Silva E, Kandiah N. Concise Cognitive Evaluation Battery (CCEB): A reliable cognitive battery for memory clinics. Abstract presented at: The SingHealth Duke-NUS Scientific Congress 2014; 2014 September 5-6; Singapore.

Kandiah N, Chander RJ, Poh YY, Cenina AR, Cheong CY, Assam PN. A prediction scale for post-stroke cognitive impairment after mild ischemic stroke. Abstract presented at: The SingHealth Duke-NUS Scientific Congress 2014; 2014 September 5-6; Singapore.

Chander RJ, Ng A, Wen MC, Kandiah N. Grey matter atrophy and white matter disease in Alzheimer’s dementia and mild cognitive impairment. Abstract presented at: The SingHealth Duke-NUS Scientific Congress 2014; 2014 September 5-6; Singapore.

Zainal NH, Chander RJ, Hameed S, Zhou J, Kandiah N. Influence of small vessel cerebrovascular disease on the neuropsychological performance of patients with early Alzheimer’s disease. Abstract presented at: The 2014 Alzheimer’s Association International Conference; 2014 July 12-17; Copenhagen, Denmark.

Lim LH, Chander RJ, Nyu MM, Choong TM, Silva E, Kandiah N. Concise Cognitive Evaluation Battery (CCEB): A reliable cognitive battery for memory clinics. Abstract presented at: The 2014 Alzheimer’s Association International Conference; 2014 July 12-17; Copenhagen, Denmark.

Kandiah N, Chander RJ, Poh YY, Cenina AR, Cheong CY, Assam PN. A prediction scale for post-stroke cognitive impairment after mild ischemic stroke. Abstract presented at: The 2014 Alzheimer’s Association International Conference; 2014 July 12-17; Copenhagen, Denmark.

Chander RJ, Ng A, Wen MC, Kandiah N. Grey matter atrophy and white matter disease in Alzheimer’s dementia and mild cognitive impairment. Abstract presented at: The 2014 Alzheimer’s Association International Conference; 2014 July 12-17; Copenhagen, Denmark.

Kandiah N, Chander RJ, Ng A, Assam PN. Effect of small vessel cerebrovascular disease on media temporal atrophy is greatest in the early stages of Alzheimer’s disease. Abstract presented at: The 66th American Academy of Neurology Annual Meeting; 2014 April 26-May 3; Philadelphia, PA.

Goh O, Chander RJ, Ng A, Kandiah N. Physical activity protects against dementia. Abstract presented at: The 3rd Singapore International Neurocognitive Symposium; 2013 April 5-6; Singapore.

Huang S, Chander RJ, Ng A, Tan LCS, Kandiah N. Apathy and depression in mild Parkinson’s disease. Abstract presented at: The 3rd Singapore International Neurocognitive Symposium; 2013 April 5-6; Singapore.

Chander RJ, Lin XL, Fernandez HP, Low A, Heng E, Marmin M, Lee KE, Kandiah N. Racial differences in silent ischemia among stroke patients. Abstract presented at: The 3rd Singapore International Neurocognitive Symposium; 2013 April 5-6; Singapore.