Clinical Research Coordinator at NNI-SG
National Neuroscience Institute, Singapore
Neurocognitive Research & Clinical Centre (NRCC), Department of Neurology
Lab head: Prof. Nagaendran Kandiah
Roles: Clinical Research Coordinator (2017 - 2018), Senior Research Assistant (2013 - 2017)
Career Highlights
Involved in study design and coordination of investigator-initiated trials, and in administration of study procedures in pharmaceutical clinical trials
Various research projects on dementia, healthy aging, Parkinson's disease, stroke, and autoimmune encephalitis
Neuropsychological assessment
Neuroimaging qualitative and volumetric analysis
Mid-level statistical analysis in Stata and SPSS
Assisting in drafting of abstracts and manuscripts for publication, and presentations in international conferences
Some wet lab experience (biological sample preparation, genomic DNA extraction)
Some volunteer involvement in dementia and brain health public awareness campaigns, and dementia caregiver support
Conferences Attended
3rd Singapore International Neurocognitive Symposium – 5-6 April 2013; Singapore
National Neuroscience Institute Research Day – 19 July 2013; Singapore
2014 Alzheimer’s Association International Conference – 12-17 July 2014; Copenhagen, Denmark
2014 SingHealth Duke-NUS Scientific Congress 2014 – 5-6 September 2014; Singapore
SingHealth Duke-NUS Neuroscience ACP Research Day – 6 February 2015; Singapore
4th Singapore International Neurocognitive Symposium – 27-28 May 2015; Singapore
2015 Alzheimer’s Association International Conference – 18-23 July 2015; Washington D.C., USA
SingHealth Duke-NUS Scientific Congress 2016 – 23-24 September 2016; Singapore
5th Singapore International Neurocognitive Symposium – 16-18 March 2017; Singapore
2017 Alzheimer’s Association International Conference – 16-20 July 2017; London, UK
My publications
While at NNI, I was involved in numerous publications on cognitive impairment, Alzheimer’s disease and other dementias, Parkinson’s disease, ischemic stroke, and other neurological conditions.
Research Projects
Investigator-initiated studies
The influence of small vessel cerebrovascular lesions on cognition and tau in Parkinson’s disease [National Neuroscience Institute, Singapore; 2013 – 2014]
Main protocol administrator
Data collection and analysis – cognitive and neuroimaging
The frequency of anti-NMDA receptor and anti-VGKC encephalitides in patients presenting with first-episode psychosis [National Neuroscience Institute, Singapore; 2013 – 2014] - Main protocol administrator
Data collection – cognitive
Multimodal connectome analysis for differentiating subtypes within early-stage dementia and mild cognitive impairment [National Neuroscience Institute, Singapore; 2013 – 2016]
Main protocol administrator
Data collection and analysis – cognitive and neuroimaging
PAWS - Parkinson's and Alzheimer's disease and impact of White matter disease Study [National Neuroscience Institute, Singapore; 2014 – present] - Data collection and analysis – cognitive and neuroimaging (2014 – 2018)
Collaborator (2018 – present)
Correlation of cognition profile and cerebral ischemia among stroke patients attending National Neuroscience Institute outpatient clinics – The Singapore Ischemic Stroke Cognitive Outcomes (SISCO) study [National Neuroscience Institute, Singapore; 2013 – present]
Main protocol administrator (2013 – 2018)
Data collection and analysis – neuroimaging visual rating (2013 – 2018)
Collaborator (2018 – present)
Study to elucidate the influence of neuroinflammation including “Damage Associated Molecular Patterns (DAMPs)” in the sundrome of Alzheimer’s disease with small vessel cerebrovascular disease (AD+svCVD) [National Neuroscience Institute, Singapore; 2014 – 2018]
Data collection – cognitive
Singapore YouNg dementia Cohort (SYNC) study: Clinical, pathophysiological, and economic cost characterization [National Neuroscience Institute, Singapore; 2015 – present]
Data collection and analysis – cognitive and neuroimaging (2015 – 2018)
Neuropsychological reports and case presentations (2015 – 2018)
Collaborator (2018 – present)
Subjective cognitive decline and objective cognitive deficits in Singaporean community elderly [National Neuroscience Institute, Singapore; 2015 – present]
Main protocol administrator (2015 – 2018)
Data collection - cognitive (2018 – present)
STROKOG international consortium of longitudinal studies of cognitive disorders following stroke [University of New South Wales; 2016 – present]
Study site coordinator (National Neuroscience Institute, Singapore; 2016 – 2018)
Collaborator (2018 – present)
Clinical effects and pathophysiology of vitamin deficiency in neurocognitive disorders: The Vitamins, brain Imaging, and Cognition - Singapore Study (VICSS) [National Neuroscience Institute, Singapore; 2017 – present]
Main protocol administrator (2017 – 2018)
Collaborator (2018 – present)
Clinical trials
Double-blind, placebo-controlled, randomized, parallel-group, 12-month safety and efficacy trial of leuco-methylthioninium bis(hydromethanesulfonate) in subjects with behavioral variant frontotemporal dementia (bvFTD) [TauRx Therapeutics]
Unblinded rater
Randomized, double-bling, placebo controlled, parallel-group, 12-month trial of leuco-methylthioninium bis(hydromethanesulfonate) in subjects with mild to moderate Alzheimer's disease study: Phase 3 [TauRx Therapeutics]
Unblinded rater
An open-label extension study of the effects of leuco-methylthioninium bis(hydromethanesulfonate) in subjects with Alzheimer's disease or behavioural variant frontotemporal dementia [TauRx Therapeutics]
Unblinded rater
Randomized, double-blind, parallel-group, placebo-controlled study of Lu AE58054 in patients with mild-moderate Alzheimers disease treated with an acetylcholinesterase inhibitor; Study 3 [Lundbeck]
Unblinded rater
Open-label trial of rivastigmine patch in subjects with mild to moderate stage Alzheimer's disease having coexisting small-vessel cerebrovascular disease [Novartis]
Unblinded rater
